Big River is a road movie where two men and a woman of different nationalities meet and come to a realization, set against the backdrop of Monument Valley, Arizona.

Ali, a Muslim man from Pakistan, is searching for his estranged wife, Nadia. He gets lost in the middle of the desert soon after arriving in the US. After meeting up with Teppei, a Japanese traveler hitchhiking his way through America, and Sarah, a beautiful white woman from a local trailer park, Ali and his new friends find Nadia living in Phoenix. To his dismay, he discovers she is living with another man. Ali spends the rest of his stay in the US. with his new friends, anxiously wondering where his life is going.

It is a story about a borderless realm of friendship and its ability to transcend cultural differences.